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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b49f47ba4523e8bb80340e4db2fdebc8b4852c9cf6f17e7bf740e19b7333d297' 
  AND token = '6PjLhBmDfyP+soKktdl2qPRRtjrBq384SvdL576jjsg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}