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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52c5889943da36cf6aa3ed89544a48ba57f89b11686952afb65daaf22a66c4f6' 
  AND token = 'K4jaDLoUwMrgoHx0CdeNroEARWevc3UjGL7Kq68VtNk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}