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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46a7247df0a6569e34bf14cabd3594fd9826702b4fcfee7b1a6a0f6274986c65' 
  AND token = 'b+iaQJ6OhkOP7wfix3yZPe/2PWWqxBHLU9nHaQAVkJ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}